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Bufotenin is a chemical constituent in the poison and eggs of several species of toads belonging to the genus Bufo, but most notably in the Colorado River toad (formerly Bufo alvarius, now Incilius alvarius) which is the only toad species in which bufotenin is present in large enough quantities for a psychoactive effect.

however, others doubt that this art provides sufficient “ethnohistorical evidence” to support the claim.

In addition to bufotenin, Bufo venoms also contain digoxin-like cardiac glycosides, and ingestion of the venom can be fatal. Ingestion of Bufo toad venom and eggs by humans has resulted in several reported cases of poisoning, some of which resulted in death.

Contemporary reports indicate that bufotenin-containing toad venom has been used as a street drug; that is, as a supposed aphrodisiac (it is not an aphrodisiac but definitely is a lethal poison), ingested orally in the form of ch’an su, and as a psychedelic, by smoking or orally ingesting Bufo toad venom or dried Bufo skins. The use of chan’su and love stone (a related toad venom preparation used as an aphrodisiac in the West Indies) has resulted in several cases of poisoning and at least one death. dmt art

Albert Most, founder of the Church of the Toad of Light and a proponent of spiritual use of Bufo alvarius venom, published a booklet titled Bufo alvarius: The Psychedelic Toad of the Sonoran Desert in 1983 which explained how to extract and smoke the secretions.

Bufotenin is also present in the skin secretion of three arboreal hylid frogs of the genus Osteocephalus (Osteocephalus taurinus, Osteocephalus oophagus, and Osteocephalus langsdorfii) from the Amazon and Atlantic rain forests. dmt art

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